Spicy Cajun Chicken Alfredo

Featured in: Weeknight Spoonfuls

This dish features tender chicken breasts seasoned with smoky Cajun spices, pan-seared to golden perfection. It’s served atop fettuccine tossed in a velvety Alfredo sauce made from butter, garlic, cream, and Parmesan cheese. A hint of smoked paprika and optional chili flakes add warmth and depth, creating a luscious, spicy flavor profile. Fresh parsley and extra Parmesan garnish the plate, enhancing aroma and taste. Ideal for those seeking a creamy pasta experience with a bold, spicy twist.

Updated on Sat, 15 Nov 2025 12:53:00 GMT
Plate of Spicy Cajun Chicken Alfredo, creamy sauce coating fettuccine, topped with sliced chicken. Save
Plate of Spicy Cajun Chicken Alfredo, creamy sauce coating fettuccine, topped with sliced chicken. | cookinget.com

A bold creamy pasta dish featuring tender Cajun-spiced chicken tossed with fettuccine in a rich Alfredo sauce is perfect for spice lovers and an exciting twist for dinner.

The first time I made this Cajun Chicken Alfredo my guests were amazed at how the spicy seasoned chicken balanced so well with the silky sauce. This dish has quickly become a favorite for our gatherings.

Ingredients

  • Boneless skinless chicken breasts: 2 large
  • Cajun seasoning: 2 tablespoons
  • Olive oil: 1 tablespoon
  • Fettuccine: 340 g (12 oz)
  • Unsalted butter: 2 tablespoons
  • Garlic: 3 cloves minced
  • Heavy cream: 1 cup (240 ml)
  • Parmesan cheese: 1 cup (100 g) freshly grated
  • Smoked paprika: 1/2 teaspoon
  • Chili flakes: 1/2 teaspoon (optional for extra heat)
  • Salt and black pepper: to taste
  • Fresh parsley: 2 tablespoons chopped
  • Extra grated Parmesan cheese: for garnish

Instructions

Cook Fettuccine:
Prepare fettuccine in salted boiling water until al dente. Reserve 1/2 cup pasta water then drain and set aside.
Season Chicken:
Pat chicken breasts dry and coat evenly with Cajun seasoning.
Cook Chicken:
Heat olive oil in a large skillet over medium-high heat. Add chicken and cook 5 6 minutes per side or until fully cooked and golden brown. Remove from skillet let rest for 5 minutes then slice thinly.
Make Alfredo Sauce:
In the same skillet reduce heat to medium and add butter. Sauté minced garlic for 1 minute until fragrant.
Finish Sauce:
Stir in heavy cream smoked paprika and chili flakes. Bring to a gentle simmer then whisk in Parmesan cheese until melted and sauce is smooth. Season with salt and pepper.
Combine & Toss:
Add cooked fettuccine to the sauce tossing to coat. If needed add reserved pasta water a little at a time for a silkier sauce.
Serve:
Top pasta with sliced Cajun chicken. Garnish with chopped parsley and extra Parmesan. Serve immediately.
Close-up of Spicy Cajun Chicken Alfredo: a rich, flavorful pasta dish with visible seasonings. Save
Close-up of Spicy Cajun Chicken Alfredo: a rich, flavorful pasta dish with visible seasonings. | cookinget.com

One night we laughed around the table as everyone raced to claim the last forkful of saucy Cajun chicken. It is now requested every month by my family.

Required Tools

Large pot large skillet tongs chef's knife cutting board measuring cups and spoons are essential for preparing this dish easily.

Allergen Information

Contains dairy and gluten. Cajun seasoning may include allergens. Always check ingredient labels to keep everyone safe at the table.

Nutritional Information

Each serving delivers about 610 calories 27 g total fat 54 g carbohydrates and 38 g protein making it a hearty meal for dinner.

Delicious Spicy Cajun Chicken Alfredo with vibrant parsley garnish, ready to enjoy with a glass of wine. Save
Delicious Spicy Cajun Chicken Alfredo with vibrant parsley garnish, ready to enjoy with a glass of wine. | cookinget.com

Serve immediately and enjoy this creamy spicy pasta. Leftovers taste great reheated for a quick meal the next day.

Recipe FAQs

How do I ensure the chicken is juicy and tender?

Pat the chicken dry before seasoning to help it brown evenly. Cook over medium-high heat without overcrowding the pan, allowing a golden crust to form while keeping the inside moist.

Can I adjust the spice level?

Yes, increase or reduce Cajun seasoning and chili flakes to suit your heat preference. Removing chili flakes will soften the kick while keeping smoky notes.

What pasta alternatives work well here?

Penne, linguine, or tagliatelle are great substitutes for fettuccine, offering similar texture and sauce adherence.

How can I make the sauce silkier?

Adding reserved pasta water little by little while tossing the pasta helps loosen and smooth the Alfredo sauce, creating a richer coating.

Is there a lighter option for the sauce?

Using half-and-half instead of heavy cream reduces richness while maintaining creaminess and body in the sauce.

Spicy Cajun Chicken Alfredo

Tender Cajun-spiced chicken paired with creamy fettuccine and a rich, flavorful sauce for a spicy meal.

Prep Duration
15 minutes
Time to Cook
25 minutes
Overall Time
40 minutes
Recipe by Sophie Daniels


Skill Difficulty Medium

Cuisine American (Cajun-inspired, Italian-American)

Output 4 Portion Count

Diet Preferences None specified

What You'll Need

Chicken

01 2 large boneless, skinless chicken breasts
02 2 tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 cup heavy cream (240 ml)
04 1 cup freshly grated Parmesan cheese (100 g)
05 ½ teaspoon smoked paprika
06 ½ teaspoon chili flakes (optional)
07 Salt and black pepper, to taste

Garnishes

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan cheese

Directions

Step 01

Cook Fettuccine: Boil salted water and cook fettuccine until al dente according to package instructions. Reserve ½ cup pasta water, then drain pasta and set aside.

Step 02

Prepare Chicken: Pat chicken dry and evenly coat with Cajun seasoning.

Step 03

Cook Chicken: Heat olive oil in a large skillet over medium-high heat. Sear chicken breasts 5 to 6 minutes per side until cooked through and golden brown. Remove, rest 5 minutes, then slice thinly.

Step 04

Sauté Garlic: Lower skillet heat to medium and add butter. Sauté minced garlic for 1 minute until fragrant.

Step 05

Make Alfredo Sauce: Stir in heavy cream, smoked paprika, and chili flakes. Simmer gently, then whisk in Parmesan until sauce is smooth. Season with salt and black pepper.

Step 06

Combine Pasta and Sauce: Add cooked fettuccine to sauce and toss to coat evenly. Add reserved pasta water gradually as needed for desired sauce consistency.

Step 07

Serve: Top pasta with sliced Cajun chicken, garnish with chopped parsley and extra Parmesan. Serve immediately.

Essential Tools

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons

Allergy Details

Review all ingredients for allergens. Ask a medical expert when uncertain.
  • Contains dairy (cream, butter, Parmesan)
  • Contains gluten (fettuccine)
  • May contain mustard or celery in Cajun seasoning; verify ingredient labels

Nutrition Facts (per portion)

These numbers offer reference only, not medical guidance.
  • Energy Value: 610
  • Fats: 27 g
  • Carbohydrates: 54 g
  • Proteins: 38 g